CAS: 755027-18-0; 1-Bromo-4-Iodo-2-Methoxybenzene

上下游产品

CAS号19056-40-7 4-溴-3-甲氧基苯胺 | CAS号932372-99-1 2-溴-5-碘苯酚 | CAS号77-78-1 硫酸二甲酯 | CAS号43192-34-3 4-溴-3-甲氧基苯甲醛 | CAS号932372-99-1 2-溴-5-碘苯酚

4-溴-3-甲氧基苯胺置于盐酸,Sodium Nitrite,Potassium Iodide体系中,用 水 作为反应溶剂,化学反应 2.0H,以100%的收率获得产物2-溴-5-碘苯甲醚
参考文献:用于合成多烯黄单胞菌素及其类似物的苯乙烯基结构单元的方法
标题:用于合成多烯黄单胞菌素及其类似物的苯乙烯基结构单元的方法
摘要:使用来自关键炔基中间体的不同硼氢化/溴硼化方法,获得了许多用于合成两种黄单胞菌素天然产物颜料以及相关类似物的芳基结构单元.在从溴化反应中分离出意想不到的区域异构体后,采用了一种新的方法来处理环周围的取代模式.探索了在这些构件上的潜在偶联反应,在关键的炔基中间体上成功进行了 Sonogashira 偶联,并通过初步 Suzuki-Miyaura 偶联和碘代硼化/heck-Mizoroki 偶联功能化了关键的脱溴苯乙烯基硼酸酯中间体.
DOI:10.1002/ejoc.201800540

专利信息

专利号:US-8591878-B2
优先权日:2008-02-25
标 题:Therapeutic compounds
发明人：MCCAULEY JOHN A; LIVERTON NIGEL J; HARPER STEVEN; MCINTYRE CHARLES J; RUDD MICHAEL T
权利人:MCCAULEY JOHN A; LIVERTON NIGEL J; HARPER STEVEN; MCINTYRE CHARLES J; RUDD MICHAEL T; MERCK SHARP & DOHME; ANGELETTI P IST RICHERCHE BIO
摘要:A class of macrocyclic compounds of formula (I), wherein R 1 , R 3 , R 4 , R a , R b , A, B, Z, M, W and n are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.

专利号:US-8278322-B2
优先权日:2005-08-01
标题 :HCV NS3 protease inhibitors
发明人：HOLLOWAY M KATHARINE; LIVERTON NIGEL J; MCCAULEY JOHN A; RUDD MICHAEL T; VACCA JOSEPH P; LUDMERER STEVEN W; OLSEN DAVID B
权利人:HOLLOWAY M KATHARINE; LIVERTON NIGEL J; MCCAULEY JOHN A; RUDD MICHAEL T; VACCA JOSEPH P; LUDMERER STEVEN W; OLSEN DAVID B; MERCK SHARP & DOHME
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

专利号:US-8138164-B2
优先权日:2006-10-24
标题:HCV NS3 protease inhibitors
发明人：LIVERTON NIGEL J; SUMMA VINCENZO; VACCA JOSEPH P
权利人:LIVERTON NIGEL J; SUMMA VINCENZO; VACCA JOSEPH P; MERCK SHARP & DOHME
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

专利号:US-8927569-B2
优先权日:2007-07-19
标 题 :Macrocyclic compounds as antiviral agents
发明人：HARPER STEVEN; SUMMA VINCENZO; LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; DI FILIPPO MARCELLO; DI FRANCESCO MARIA EMILIA; FERRARA MARCO; ROMANO JOSEPH J; RUDD MICHAEL T
权利人:HARPER STEVEN; SUMMA VINCENZO; LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; DI FILIPPO MARCELLO; DI FRANCESCO MARIA EMILIA; FERRARA MARCO; ROMANO JOSEPH J; RUDD MICHAEL T; MERCK SHARP & DOHME
摘要:A class of macrocyclic compounds of formula (I), wherein R 1 , R 3 , R 4 , R a , R b , A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):

专利号:US-8377874-B2
优先权日:2006-10-27
标题 :HCV NS3 protease inhibitors
发明人：LIVERTON NIGEL J; VACCA JOSEPH P; MCCAULEY JOHN A; RUDD MICHAEL T
权利人:MERCK SHARP & DOHME; LIVERTON NIGEL J; VACCA JOSEPH P; MCCAULEY JOHN A; RUDD MICHAEL T
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.