CAS: 872-36-6; Vinylene Carbonate

相似化合物

37830-90-3 80715-22-6 62458-19-9

上下游产品

CAS号3967-54-2 氯代碳酸乙烯酯(CEC) | CAS号96-49-1 碳酸乙烯酯 | CAS号60-29-7 乙醚 | CAS号121-44-8 三乙胺 | CAS号110-71-4 乙二醇二甲醚 | CAS号3967-55-3 4,5-二氯-1,3-二氧五环-2-酮 | CAS号71-43-2 苯 | CAS号3967-55-3 4,5-二氯-1,3-二氧五环-2-酮 | CAS号40101-17-5 3,3'-二甲氧基苯偶酰 | CAS号176961-50-5 2-(4-溴苯基)恶唑 | CAS号3457-46-3 4,4'-二氯苯偶酰 | CAS号463-51-4 乙烯酮 | CAS号79-20-9 乙酸甲酯 | CAS号124-38-9 二氧化碳 | CAS号108-24-7 乙酸酐 | CAS号3457-48-5 4,4'-二甲基联苯甲酰

氯代碳酸乙烯酯置于sodium Cyanoborohydride,三乙胺体系中,用94 %的收率获得产物碳酸亚乙烯酯
参考文献:制备碳酸亚乙烯酯的方法
标题:制备碳酸亚乙烯酯的方法
摘要:本发明涉及一种制备碳酸亚乙烯酯的方法,包括:(1)提供第一物料,其中,所述第一物料包含氯代碳酸乙烯酯,硼氢化物和能够溶解氯代碳酸乙烯酯和所述硼氢化物的溶剂s1;(2)提供第二物料,其中,所述第二物料包含三乙胺;(3)将所述第一物料和所述第二物料进料到反应器的反应区中,反应形成碳酸亚乙烯酯.本发明所提供的合成方法有效地提高了反应的效率,具有突出的经济价值.

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:US-11220513-B2
优先权日:2015-04-30
标题:Chromium-mediated coupling and application to the synthesis of halichondrins
发明人：KISHI YOSHITO; YAN WUMING; LI JINGWEI; LI ZHANJIE; YAHATA KENZO
权利人:HARVARD COLLEGE
摘要:The present invention provides unified synthesis of the C1-C19 building blocks of halichondrins and analogs thereof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hybridized carbon. The provided efficient selective coupling reactions can allow easy access to the C1-C19 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates.

专利号:US-2024383940-A1
优先权日:2021-03-31
标题 :Synthesis of trinucleotide and tetranucleotide caps for mrna production
发明人：ENDO ATSUSHI
权利人:MODERNA TX INC
摘要:Provided herein are methods of making trinucleotides and tetranucleotides for use as 5′ mRNA caps. The methods utilize a novel “top-down†strategy and provide for synthesis of oligonucleotides with higher yields and increased efficiency compared to traditional methods. A key step of the methods disclosed, herein can also be adapted to utilize a “one-pot†approach, resulting in an increase in the yield of the final oligonucleotide product.