CAS: 98-68-0; 4-Methoxybenzene-1-Sulfonyl Chloride

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CAS号696-63-9 对甲氧基苯硫酚 | CAS号5335-87-5 4,4'-二甲氧基二苯二硫醚 | CAS号24197-73-7 S-(p-methoxyphe... | CAS号100-66-3 苯甲醚 | CAS号60787-31-7 S-(4-methoxyphe... | CAS号26905-24-8 1-benzylsulfany... | CAS号104-92-7 对溴苯甲醚 | CAS号5857-42-1 4-甲氧基苯磺酸 | CAS号104-94-9 对甲氧基苯胺 | CAS号5153-67-3 反式硝基苯乙烯 | CAS号105411-91-4 5-bromo-1-(4-me... | CAS号111711-51-4 5-ethoxy-1-(4-m... | CAS号105434-88-6 5-fluoro-1-(4-m... | CAS号5335-87-5 4,4'-二甲氧基二苯二硫醚 | CAS号696-63-9 对甲氧基苯硫酚 | CAS号3517-90-6 4-甲氧基苯急家基砜 | CAS号40280-00-0 2-{[((4-甲氧基苯基)磺... | CAS号195052-28-9 2-[benzyl-(4-me... | CAS号22017-57-8 ethyl 4-methoxy...

4,4'-二甲氧基二苯二硫置于1,3-二氯-5,5-二甲基海因,溶剂黄146体系中,用 二氯甲烷,水 作为反应溶剂,以92%的收率获得产物对甲氧基苯磺酰氯
参考文献:一种简单且高效的氧化氯化方案,用于制备芳磺酰氯
标题:一种简单且高效的氧化氯化方案,用于制备芳磺酰氯
摘要:发现2,4-二氯-5,5-二甲基乙内酰脲(dcdmh)是一种温和而有效的试剂,可通过氧化氯化以高至极好的收率将硫化合物直接氧化转化为相应的芳烃磺酰氯.该方法适用于多种类型的硫底物(硫醇,二硫化物和苄基硫化物).整个过程简单,实用,并且可以方便地获得各种芳基或杂芳基磺酰氯.温和的反应条件和广泛的底物范围使该方法对现有的芳基或杂芳基磺酰氯合成方法具有吸引力和互补性.
DOI:10.1016/j.Tetlet.2009.11.047

专利信息

专利号:US-12139504-B2
优先权日:2022-08-09
标 题:Vanadium alkylidene complex, synthesis and use thereof
发明人：BUKHRYAKOV KONSTANTIN; BELOV DMITRY
权利人:BUKHRYAKOV KONSTANTIN; BELOV DMITRY; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, RCM reactions. Specifically, the subject invention provides the synthesis of the first catalytically active V oxo alkylidene, VO(CHSiMe 3 )(PEt 3 ) 2 Cl, which exhibits superior performance compared to other analogs.

专利号:US-9650330-B2
优先权日:2013-12-12
标题 :Process for the synthesis of aryl sulfones
发明人：MHASKE SANTOSH BABURAO; PANDYA VIRAT
权利人:COUNCIL SCIENT IND RES
摘要:The present patent discloses a novel, efficient and transition-metal-free room temperature single step process for synthesis of aryl sulfones and substituted aryl sulfones starting from aryl substrates.

专利号:WO-2020255049-A1
优先权日:2019-06-20
标题:Process for the preparation and identification of deuterated eugenol
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present invention provides a novel, simple, unique and viable processes for the synthesis of deuterium incorporated eugenols, such as deuterated eugenol (II), regioisomeric deuterated eugenol (III), and deuterated variant of methyl eugenol (V).

专利号:US-6448058-B1
优先权日:1997-09-12
标 题:Methods for solid phase synthesis of mercapto compounds and derivatives, combinatorial libraries thereof and compositions obtained thereby
发明人：PATEL DINESH V; NGU KHEHYONG; ZHOU JIANPING
权利人:VERSICOR INC
摘要:Methods of preparing combinatorial libraries of mercapto (thiol) compounds them and compositions obtained therefrom are disclosed. The compounds are synthesized on a solid support. Following synthesis, the compounds are optionally cleaved from the support. One such method of synthesis involves attack of an S-protected nucleophile on a resin functionalized with a leaving group. The invention also provides for screening the mercapto compounds for bioactive compounds; in particular, for inhibitors of MMPs.

专利号:WO-9946267-A1
优先权日:1998-03-12
标题 :Modulators of protein tyrosine phosphatases (ptpases)
发明人：MOELLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILIAM CHARLES; GE YU; UYEDA ROY TERUYUKI
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-10675366-B2
优先权日:2016-08-12
标 题 :Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2
发明人：BEINAT CORRINE GAYE; ALAM ISRAT SHAMIMA; JAMES MICHELLE L; GAMBHIR SANJIV S; SRINIVASAN ANANTH
权利人:UNIV LELAND STANFORD JUNIOR
摘要:The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([18F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively measure its expression through the development of PKM2-specific radiopharmaceuticals. Precursors useful for the synthesis of the radiolabeled [18F]DASA-23-PKM2-specific probe and related compounds, and their methods of synthesis, are provided. Since the half-life of the 18F isotope is approximately 110 min, it is advantageous for a practitioner to attach the radionuclide to the precursor shortly before administration. Therefore, a precursor compound suitable for receiving the radionuclide and capable of specifically binding to the PKM2 variant can be provided.