专利号:US-2008214637-A1 优先权日:2004-11-11 标题 :Process for the Synthesis of Tetrazoles 发明人:ANTONCIC LJUBOMIR; LUDESCHER JOHANNES 权利人:LEK PHARMACEUTICALS 摘要:A process for the synthesis of tetrazol derivative has been developed which starts from a tetrazole derivative where acidic hydrogen atom has been replaced by a protecting group and the deprotection is performed with a catalytic amount of organic acid and can proceed in an aqueous solvent.
专利号:US-7098342-B2 优先权日:2003-10-16 标题 :Preparation of candesartan cilexetil 发明人:ETINGER MARINA YU; FEDOTEV BORIS; DOLITZKY BEN-ZION 权利人:TEVA PHARMA 摘要:The invention encompasses processes for the synthesis of cilexetil trityl candesartan from the reaction of trityl candesartan with cilexetil halide in the presence of a base and a low boiling organic solvent. Optionally, the reaction may be conducted in the presence of a phase transfer catalyst.
专利号:WO-2006050922-A1 优先权日:2004-11-11 标 题:Process for the synthesis of tetrazoles
专利号:EP-1812423-A1 优先权日:2004-11-11 标 题 :Process for the synthesis of tetrazoles
专利号:US-7879906-B2 优先权日:2006-11-24 标 题 :GABA analogs, compositions and methods for manufacturing thereof 发明人:HWANG JENN-TSANG; HWANG CHRONG-SHIONG; CHANG YOW-LONE; YAO CHUNG-NIANG 权利人:ANCHEN LAB INC 摘要:The invention provides compounds of Formula (I), pharmaceutical compositions and methods of synthesis thereof.
专利号:CN-102887890-B 优先权日:2012-11-06 标题:Synthesis method of candesartan cilexetil
参考文献:10.1055/s-0032-1317131 摘要:Seki M. An Efficient C–H Arylation of a 5-Phenyl-1H-tetrazole Derivative: A Practical Synthesis of an Angiotensin II Receptor Blocker. Synthesis. 2012 Aug 21;44(20):3231–7. doi: 10.1055/s-0032-1317131. 参考文献:10.1055/s-0032-1317726 摘要:Synthesis of Candesartan Cilexetil. Synfacts. 2012 Dec 17;9(01):0006. doi: 10.1055/s-0032-1317726.